U-Shaped Dose-Responses in Biology, Toxicology, and Public Health
نویسندگان
چکیده
منابع مشابه
U-shaped dose-responses in biology, toxicology, and public health.
The occurrence of U-shaped dose-response relationships (often termed hormesis) has been documented in numerous biological, toxicological, and pharmacological investigations. Many of the endpoints studied are of considerable significance to public health (e.g. body weight, cholesterol levels, ethanol consumption, longevity, cancer incidence, etc). Despite the fact that U-shaped dose-responses ar...
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Hormesis has been defined as a dose-response relationship in which there is a stimulatory response at low doses, but an inhibitory response at high doses, resulting in a U- or inverted U-shaped dose response. To assess the proportion of studies satisfying criteria for evidence of hormesis, a database was created from published toxicological literature using rigorous a priori entry and evaluativ...
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Interventions that alter population-level risk exposure haveyieldedanumberof improvements inpublichealth. Tobaccotaxesareanexampleofsuchpopulation-basedapproachestodiseaseprevention. Inthecaseoftobacco,the harmsofshiftingtotalpopulationexposurethroughtaxationareminimal,becausethereisnosafelevelofconsumption. However, other risk factors do not exhibit the same linear relationshipbetweenexposurea...
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ژورنال
عنوان ژورنال: Annual Review of Public Health
سال: 2001
ISSN: 0163-7525,1545-2093
DOI: 10.1146/annurev.publhealth.22.1.15